Blood plasma cathepsin S in severe bronchial asthma

The aim . To determine the level of cathepsin S and to identify its possible relationships with clinical, functional laboratory indicators in patients severe bronchial asthma. Methods 114 asthma were examined. 96 women (84.2%) 18 (15.8%) men divided into 2 groups: allergic non-allergic external respiration function was assessed whole-body plethysmography (“Erich Jaeger”, Germany). plasma concentration cytokines IL-4, IL-5, IL-13, periostin, S, TGF-β estimated ELISA (“eBioscience”, USA). Results Fixed obstruction is reported 48% 50% cases asthma, respectively. Peripheral blood eosinophilia occurs 41.5% 25% levels increased both groups. An increase IL-4 revealed Periostin as compared control second group. Positive correlation between IL-5 established We identified weak positive clinical symptoms disease, such frequency SABA use asphyxiation attacks, only A Conclusion serum found moderate relationship may indirectly indicate involvement airway remodeling processes regardless disease type.